GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4⁺ T Cells and Is Immunosuppressive in Type 1 Diabetes.

ABSTRACT: The neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule in the brain and in pancreatic islets. Here, we demonstrate that GABA regulates cytokine secretion from human peripheral blood mononuclear cells (PBMCs) and CD4⁺ T cells. In anti-CD3 stimulated PBMCs, GABA (100nM) inhibited release of 47 cytokines in cells from patients with type 1 diabetes (T1D), but only 16 cytokines in cells from nondiabetic (ND) individuals. CD4⁺ T cells from ND individuals were grouped into responder or non-responder T cells according to effects of GABA (100nM, 500nM) on the cell proliferation. In the responder T cells, GABA decreased proliferation, and inhibited secretion of 37 cytokines in a concentration-dependent manner. In the non-responder T cells, GABA m

SUBMITTER: Bhandage AK 

PROVIDER: S-EPMC5952354 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature