The role of cell body density in ruminant retina mechanics assessed by atomic force and Brillouin microscopy.

ABSTRACT: Cells in the central nervous system (CNS) respond to the stiffness of their environment. CNS tissue is mechanically highly heterogeneous, thus providing motile cells with region-specific mechanical signals. While CNS mechanics has been measured with a variety of techniques, reported values of tissue stiffness vary greatly, and the morphological structures underlying spatial changes in tissue stiffness remain poorly understood. We here exploited two complementary techniques, contact-based atomic force microscopy and contact-free Brillouin microscopy, to determine the mechanical properties of ruminant retinae, which are built up by different tissue layers. As in all vertebrate retinae, layers of high cell body densities ('nuclear layers') alternate with layers of low cell body densities ('pl

SUBMITTER: Weber IP 

PROVIDER: S-EPMC5952364 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature