Irreversible Electroporation in the Epidural Space of the Porcine Spine: Effects on Adjacent Structures.

ABSTRACT: Purpose To determine the effects of irreversible electroporation (IRE) on the neural tissues after ablation in the epidural space of the porcine spine. Materials and Methods The institutional animal care and use committee approved this study. With the IRE electrode positioned in the right lateral recess of the spinal epidural space, 20 IRE ablations were performed with computed tomographic (CT) guidance by using different applied voltages in four animals that were euthanized immediately after magnetic resonance (MR) imaging of the spine, performed 6 hours after IRE (terminal group). Histopathologic characteristics of the neural tissues were assessed and used to select a voltage for a survival study. Sixteen CT-guided IRE ablations in the epidural space were performed by using 667 V in four

SUBMITTER: Tam AL 

PROVIDER: S-EPMC5952366 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature