Hyperthermophilic Archaeon Thermococcus kodakarensis Utilizes a Four-Step Pathway for NAD⁺ Salvage through Nicotinamide Deamination.

ABSTRACT: Many organisms possess pathways that regenerate NAD⁺ from its degradation products, and two pathways are known to salvage NAD⁺ from nicotinamide (Nm). One is a four-step pathway that proceeds through deamination of Nm to nicotinic acid (Na) by Nm deamidase and phosphoribosylation to nicotinic acid mononucleotide (NaMN), followed by adenylylation and amidation. Another is a two-step pathway that does not involve deamination and directly proceeds with the phosphoribosylation of Nm to nicotinamide mononucleotide (NMN), followed by adenylylation. Judging from genome sequence data, the hyperthermophilic archaeon Thermococcus kodakarensis is supposed to utilize the four-step pathway, but the fact that the adenylyltransferase encoded by TK0067 recognizes both NMN and

SUBMITTER: Hachisuka SI 

PROVIDER: S-EPMC5952396 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature