Fecal Microbiota Composition Drives Immune Activation in HIV-infected Individuals.

ABSTRACT: The inflammatory properties of the enteric microbiota of Human Immunodeficiency Virus (HIV)-infected individuals are of considerable interest because of strong evidence that bacterial translocation contributes to chronic immune activation and disease progression. Altered enteric microbiota composition occurs with HIV infection but whether altered microbiota composition or increased intestinal permeability alone drives peripheral immune activation is controversial. To comprehensively assess the inflammatory properties of HIV-associated enteric microbiota and relate these to systemic immune activation, we developed methods to purify whole fecal bacterial communities (FBCs) from stool for use in in vitro immune stimulation assays with human cells. We show that the enteric microbiota of untrea

SUBMITTER: Neff CP 

PROVIDER: S-EPMC5952409 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature