HmmIBD: software to infer pairwise identity by descent between haploid genotypes.

ABSTRACT:

Background

A number of recent malaria studies have used identity by descent (IBD) to study epidemiological processes relevant to malaria control. In this paper, a software package, hmmIBD, is introduced for estimating pairwise IBD between haploid genomes, such as those of the malaria parasite, sampled from one or two populations. Source code is freely available.

Methods

The performance of hmmIBD was verified using simulated data and benchmarked against an existing method for detecting IBD within populations. Code for all tests is freely available. The utility of hmmIBD for detecting IBD across populations was demonstrated using Plasmodium falciparum data from Cambodia and Ghana.

Results

Alongside an existing method, hmmIBD was highly accurate, sensitive and specific.

SUBMITTER: Schaffner SF 

PROVIDER: S-EPMC5952413 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature