Controlled Human Hookworm Infection: Accelerating Human Hookworm Vaccine Development.

ABSTRACT:

Background

Controlled human hookworm infection (CHHI) is a central component of a proposed hookworm vaccination-challenge model (HVCM) to test the efficacy of candidate vaccines. Critical to CHHI is the manufacture of Necator americanus infective larvae (NaL3) according to current Good Manufacturing Practice (cGMP) and the determination of an inoculum of NaL3 that is safe and reliably induces patent infection.

Methods

cGMP-grade NaL3 were produced for a phase 1 trial in 20 healthy, hookworm-naïve adults in the United States, who received either 25 or 50 NaL3. Participants were monitored for 12-18 weeks postinfection for safety, tolerability, and patency of N. americanus infection.

Results

Both NaL3 doses were well toler

SUBMITTER: Diemert D 

PROVIDER: S-EPMC5952933 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature