Sixty-five years of the long march in protein secondary structure prediction: the final stretch?

ABSTRACT: Protein secondary structure prediction began in 1951 when Pauling and Corey predicted helical and sheet conformations for protein polypeptide backbone even before the first protein structure was determined. Sixty-five years later, powerful new methods breathe new life into this field. The highest three-state accuracy without relying on structure templates is now at 82-84%, a number unthinkable just a few years ago. These improvements came from increasingly larger databases of protein sequences and structures for training, the use of template secondary structure information and more powerful deep learning techniques. As we are approaching to the theoretical limit of three-state prediction (88-90%), alternative to secondary structure prediction (prediction of backbone torsion angles and Cα-a

SUBMITTER: Yang Y 

PROVIDER: S-EPMC5952956 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature