Maternal folate genes and aberrant DNA hypermethylation in pediatric acute lymphoblastic leukemia.

ABSTRACT:

Background

There is evidence that maternal genotypes in folate-related genes are associated with pediatric acute lymphoblastic leukemia (ALL) independent of offspring genotype. We evaluated the relationship between maternal genotypes in methionine synthase (MTR) and DNA methylation status in ALL to better characterize the molecular mechanism underlying this association.

Procedure

We obtained bone marrow samples from 51 patients with ALL at diagnosis and from 6 healthy donors. Mothers of patients provided a saliva sample and were genotyped at 11 tagSNPs in MTR. DNA methylation was measured in bone marrow mononuclear cells of patients and six healthy marrow donors. We used hierarchical clustering to identify patients with a hypermethylator phenotype based on 281 differentially

SUBMITTER: Schraw JM 

PROVIDER: S-EPMC5953491 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature