Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α⁺thalassaemia.

ABSTRACT: Malaria has been a major driving force in the evolution of the human genome. In sub-Saharan African populations, two neighbouring polymorphisms in the Complement Receptor One (CR1) gene, named Sl2 and McC^b, occur at high frequencies, consistent with selection by malaria. Previous studies have been inconclusive. Using a large case-control study of severe malaria in Kenyan children and statistical models adjusted for confounders, we estimate the relationship between Sl2 and McC^b and malaria phenotypes, and find they have opposing associations. The Sl2 polymorphism is associated with markedly reduced odds of cerebral malaria and death, while the McC^b polymorphism is associated with increased odds of cerebral mal

SUBMITTER: Opi DH 

PROVIDER: S-EPMC5953541 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature