Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms.

ABSTRACT: Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as frequent in patients with diabetes compared with those who do not have diabetes. Moreover, patients with hypertension often exhibit insulin resistance and are at greater risk of diabetes developing than are normotensive individuals. The major cause of morbidity and mortality in diabetes is cardiovascular disease, which is exacerbated by hypertension. Accordingly, diabetes and hypertension are closely interlinked because of similar risk factors, such as endothelial dysfunction, vascular inflammation, arterial remodelling, atherosclerosis, dyslipidemia, and obesity. There is also substantial overlap in the cardiovascular complications of diabetes and hypertension related primarily to microvascular and macrova

SUBMITTER: Petrie JR 

PROVIDER: S-EPMC5953551 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature