Detection of HIV-1-specific gastrointestinal tissue resident CD8⁺ T-cells in chronic infection.

ABSTRACT: Tissue-resident memory (T_RM) CD8⁺ T-cells are non-recirculating, long-lived cells housed in tissues that can confer protection against mucosal pathogens. Human immunodeficiency virus-1 (HIV-1) is a mucosal pathogen and the gastrointestinal tract is an important site of viral pathogenesis and transmission. Thus, CD8⁺ T_RM cells may be an important effector subset for controlling HIV-1 in mucosal tissues. This study sought to determine the abundance, phenotype, and functionality of CD8⁺ T_RM cells in the context of chronic HIV-1 infection. We found that the majority of rectosigmoid CD8⁺ T-cells were CD69⁺CD103⁺S1PR1^- and T-bet^LowEomesodermin^Neg, indicative of a ti

SUBMITTER: Kiniry BE 

PROVIDER: S-EPMC5953759 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature