Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms.

ABSTRACT:

Objectives

Many studies have reported the increased presence of gastrointestinal (GI) symptoms in children with autism spectrum disorders (ASD). Altered microbiome profiles, pro-inflammatory responses and impaired intestinal permeability have been observed in children with ASD and co-morbid GI symptoms, yet few studies have compared these findings to ASD children without GI issues or similarly aged typical developing children. The aim of this study was to determine whether there are biological signatures in terms of immune dysfunction and microbiota composition in children with ASD with GI symptoms.

Methods

Children were enrolled in one of four groups: ASD and GI symptoms of irregular bowel habits (ASD^GI), children with ASD but without current or previous GI sympt

SUBMITTER: Rose DR 

PROVIDER: S-EPMC5953830 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature