Minority stress and leukocyte gene expression in sexual minority men living with treated HIV infection.

ABSTRACT: Sexual minority (i.e., non-heterosexual) individuals experience poorer mental and physical health, accounted for in part by the additional burden of sexual minority stress occurring from being situated in a culture favoring heteronormativity. Informed by previous research, the purpose of this study was to identify the relationship between sexual minority stress and leukocyte gene expression related to inflammation, cancer, immune function, and cardiovascular function. Sexual minority men living with HIV who were on anti-retroviral medication, had viral load < 200 copies/mL, and had biologically confirmed, recent methamphetamine use completed minority stress measures and submitted blood samples for RNA sequencing on leukocytes. Differential gene expression and pathway analyses were conducte

SUBMITTER: Flentje A 

PROVIDER: S-EPMC5953835 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature