Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer.
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ABSTRACT:
SUBMITTER: Hellmann MD
PROVIDER: S-EPMC5953836 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer.
Hellmann Matthew D MD Nathanson Tavi T Rizvi Hira H Creelan Benjamin C BC Sanchez-Vega Francisco F Ahuja Arun A Ni Ai A Novik Jacki B JB Mangarin Levi M B LMB Abu-Akeel Mohsen M Liu Cailian C Sauter Jennifer L JL Rekhtman Natasha N Chang Eliza E Callahan Margaret K MK Chaft Jamie E JE Voss Martin H MH Tenet Megan M Li Xue-Mei XM Covello Kelly K Renninger Andrea A Vitazka Patrik P Geese William J WJ Borghaei Hossein H Rudin Charles M CM Antonia Scott J SJ Swanton Charles C Hammerbacher Jeff J Merghoub Taha T McGranahan Nicholas N Snyder Alexandra A Wolchok Jedd D JD
Cancer cell 20180412 5
Combination immune checkpoint blockade has demonstrated promising benefit in lung cancer, but predictors of response to combination therapy are unknown. Using whole-exome sequencing to examine non-small-cell lung cancer (NSCLC) treated with PD-1 plus CTLA-4 blockade, we found that high tumor mutation burden (TMB) predicted improved objective response, durable benefit, and progression-free survival. TMB was independent of PD-L1 expression and the strongest feature associated with efficacy in mult ...[more]
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