Image-based SPECT calibration based on the evaluation of the Fraction of Activity in the Field of View.

ABSTRACT: BACKGROUND:SPECT quantification is important for dosimetry in targeted radionuclide therapy (TRT) and the calibration of SPECT images is a crucial stage for image quantification. The current standardized calibration protocol (MIRD 23) uses phantom acquisitions to derive a global calibration factor in specific conditions. It thus requires specific acquisitions for every clinical protocols. We proposed an alternative and complementary image-based calibration method that allows to determine a calibration factor adapted to each patient, radionuclide, and acquisition protocol and that may also be used as an additional independent calibration. RESULTS:The proposed method relies on a SPECT/CT acquisition of a given region of interest and an initial whole-body (WB) planar image. First, the conjuga

SUBMITTER: Halty A 

PROVIDER: S-EPMC5953912 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature