First validation of myocardial flow reserve assessed by dynamic ^99mTc-sestamibi CZT-SPECT camera: head to head comparison with ¹⁵O-water PET and fractional flow reserve in patients with suspected coronary artery disease. The WATERDAY study.

ABSTRACT:

Purpose

We assessed the feasibility of myocardial blood flow (MBF) and flow reserve (MFR) estimation using dynamic SPECT with a novel CZT camera in patients with stable CAD, in comparison with ¹⁵O-water PET and fractional flow reserve (FFR).

Methods

Thirty patients were prospectively included and underwent FFR measurements in the main coronary arteries (LAD, LCx, RCA). A stenosis ≥50% was considered obstructive and a FFR abnormal if ≤0.8. All patients underwent a dynamic rest/stress ^99mTc-sestamibi CZT-SPECT and ¹⁵O-water PET for MBF and MFR calculation. Net retention kinetic modeling was applied to SPECT data to estimate global uptake values, and MBF was derived using Leppo correction. Ischemia by PET and CZT-SPECT was considered present if

SUBMITTER: Agostini D 

PROVIDER: S-EPMC5953996 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature