IL-15 Overcomes Hepatocellular Carcinoma-Induced NK Cell Dysfunction.

ABSTRACT: NK cells have potent antitumor capacity. They are enriched in the human liver, with a large subset specialized for tissue-residence. The potential for liver-resident versus liver-infiltrating NK cells to populate, and exert antitumor functions in, human liver tumors has not been studied. We examined liver-resident and liver-infiltrating NK cells directly ex vivo from human hepatocellular carcinomas (HCCs) and liver colorectal (CRC) metastases, compared with matched uninvolved liver tissue. We found that NK cells were highly prevalent in both HCC and liver CRC metastases, although at lower frequencies than unaffected liver. Up to 79% of intratumoral NK cells had the CXCR6⁺CD69⁺ liver-resident phenotype. Direct ex vivo staining showed that liver-resident N

SUBMITTER: Easom NJW 

PROVIDER: S-EPMC5954038 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature