Activin receptors regulate the oligodendrocyte lineage in health and disease.

ABSTRACT: The most prevalent neurological disorders of myelin include perinatal brain injury leading to cerebral palsy in infants and multiple sclerosis in adults. Although these disorders have distinct etiologies, they share a common neuropathological feature of failed progenitor differentiation into myelin-producing oligodendrocytes and lack of myelin, for which there is an unmet clinical need. Here, we reveal that a molecular pathology common to both disorders is dysregulation of activin receptors and that activin receptor signaling is required for the majority of myelin generation in development and following injury. Using a constitutive conditional knockout of all activin receptor signaling in oligodendrocyte lineage cells, we discovered this signaling to be required for myelination via regulat

SUBMITTER: Dillenburg A 

PROVIDER: S-EPMC5954071 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature