Acute Noise Exposure Is Associated With Intrinsic Apoptosis in Murine Central Auditory Pathway.

ABSTRACT: Noise that is capable of inducing the hearing loss (NIHL) has a strong impact on the inner ear structures and causes early and most obvious pathophysiological changes in the auditory periphery. Several studies indicated that intrinsic apoptotic cell death mechanisms are the key factors inducing cellular degeneration immediately after noise exposure and are maintained for days or even weeks. In addition, studies demonstrated several changes in the central auditory system following noise exposure, consistent with early apoptosis-related pathologies. To clarify the underlying mechanisms, the present study focused on the noise-induced gene and protein expression of the pro-apoptotic protease activating factor-1 (APAF1) and the anti-apoptotic B-cell lymphoma 2 related protein a1a (BCL2A1A) in t

SUBMITTER: Groschel M 

PROVIDER: S-EPMC5954103 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature