Impacts of Acute Hypoxia on Alzheimer's Disease-Like Pathologies in APP^swe/PS1^dE9 Mice and Their Wild Type Littermates.

ABSTRACT: Alzheimer's disease (AD) is the most common form of dementia and pathologically featured by β-amyloid (Aβ) plaque deposition and hyper-phosphorylated tau aggregation in the brain. Environmental factors are believed to contribute to the pathogenesis and progression of AD. In the present study, we investigated the impacts of acute hypoxia on Aβ and tau pathologies, neuroinflammation, mitochondrial function, and autophagy in APP^swe/PS1^dE9 AD mouse model. Male APP^swe/PS1^dE9 transgenic (Tg) mice and their age-matched wild type (Wt) littermates were exposed to one single acute hypoxic episode (oxygen 7%) for 24 h. We found that acute hypoxia exposure increased the expressions of amyloid precursor protein (APP), anterior pharynx-defective 1 (APH1) and c

SUBMITTER: Zhang F 

PROVIDER: S-EPMC5954115 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature