Two-years Postradiotherapy Biopsies: Lessons from MRC RT01 Trial.

ABSTRACT:

Background

The importance of 2-yr postradiotherapy prostate biopsy status remains uncertain.

Objective

To assess the value of 2 year post treatment biopsies in a randomised trial of radiotherapy dose escalation.

Design, setting, and participants

Between 1998 and 2001, 843 men with localised prostate cancer were randomised to receive either control-64Gy or escalated-74Gy conformal radiotherapy (CFRT) in the MRC RT01 trial in combination with 3-6-mo neoadjuvant androgen deprivation therapy. Prostate biopsies were planned at 2 yr from start of CFRT in suitable men.

Outcome measurements and statistical analysis

Prostate biopsy results and prostate-specific antigen (PSA) levels performed at 2 yr post-CFRT were evaluated with long-term biochemical progression free su

SUBMITTER: Kass-Iliyya A 

PROVIDER: S-EPMC5954168 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature