CagY-Dependent Regulation of Type IV Secretion in Helicobacter pylori Is Associated with Alterations in Integrin Binding.

ABSTRACT: Strains of Helicobacter pylori that cause ulcer or gastric cancer typically express a type IV secretion system (T4SS) encoded by the cag pathogenicity island (cagPAI). CagY is an ortholog of VirB10 that, unlike other VirB10 orthologs, has a large middle repeat region (MRR) with extensive repetitive sequence motifs, which undergo CD4⁺ T cell-dependent recombination during infection of mice. Recombination in the CagY MRR reduces T4SS function, diminishes the host inflammatory response, and enables the bacteria to colonize at a higher density. Since CagY is known to bind human α₅β₁ integrin, we tested the hypothesis that recombination in the CagY MRR regulates T4SS function by modulating binding to α₅β₁ integrin. Usin

SUBMITTER: Skoog EC 

PROVIDER: S-EPMC5954226 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature