Vinculin Force-Sensitive Dynamics at Focal Adhesions Enable Effective Directed Cell Migration.

ABSTRACT: Cell migration is a complex process, requiring coordination of many subcellular processes including membrane protrusion, adhesion, and contractility. For efficient cell migration, cells must concurrently control both transmission of large forces through adhesion structures and translocation of the cell body via adhesion turnover. Although mechanical regulation of protein dynamics has been proposed to play a major role in force transmission during cell migration, the key proteins and their exact roles are not completely understood. Vinculin is an adhesion protein that mediates force-sensitive processes, such as adhesion assembly under cytoskeletal load. Here, we elucidate the mechanical regulation of vinculin dynamics. Specifically, we paired measurements of vinculin loads using a Förster r

SUBMITTER: Rothenberg KE 

PROVIDER: S-EPMC5954296 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature