Validation of the Sepsis MetaScore for Diagnosis of Neonatal Sepsis.

ABSTRACT:

What’s known on this subject

Neonates are at increased risk for developing sepsis, but this population often exhibits ambiguous clinical signs that complicate the diagnosis of infection. No biomarker has yet shown enough diagnostic accuracy to rule out sepsis at the time of clinical suspicion.

What this study adds

We show that a gene-expression-based signature is an accurate objective measure of the risk of sepsis in a neonate or preterm infant, and it substantially improves diagnostic accuracy over that of commonly used laboratory-based testing. Implementation might decrease inappropriate antibiotic use.

Background

Neonatal sepsis can have devastating consequences, but accurate diagnosis is difficult. As a result, up to 200 neonates with suspected sepsis are treated

SUBMITTER: Sweeney TE 

PROVIDER: S-EPMC5954302 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature