Myelin status is associated with change in functional mobility following slope walking in people with multiple sclerosis.

ABSTRACT:

Background

The level of myelin disruption in multiple sclerosis patients may impact the capacity for training-induced neuroplasticity and the magnitude of therapeutic response to rehabilitation interventions. Downslope walking has been shown to increase functional mobility in individuals with multiple sclerosis, but it is unclear if myelin status influences therapeutic response.

Objective

The current study aimed to examine the relationship between baseline myelin status and change in functional mobility after a walking intervention.

Methods

The Timed Up and Go test was used to measure functional mobility before and after completion of a repeated, six-session slope walking intervention in 16 participants with relapsing-remitting multiple sclerosis. Multi-component T

SUBMITTER: King EM 

PROVIDER: S-EPMC5954324 | biostudies-literature | 2018 Apr-Jun

REPOSITORIES: biostudies-literature