TGFB1 and LAMA1 gene polymorphisms in children with high myopia.

ABSTRACT:

Objective

To investigate TGFB1 and LAMA1 gene polymorphisms in children with high myopia in order to determine the genetic basis of large myopic shifts causing severe visual impairment and complications.

Methods

Seventy-four children with high myopia (≥6 diopters [D]; study group) and 77 emmetropic children (±0.5D; control group) were included. Genetic and polymorphism analyses were performed in the Medical Genetics Laboratory using DNA purified from the patients' blood samples.

Results

Mean ages of the patients were 7.1±3 (3-13) and 9.6±1.8 (6-13) years in the study and control groups, respectively. Mean refraction in the high myopia group were -10.1±4.3D in the right and -8.9±3.6D in the left eye. LAMA1 gene analysis of the study group revealed

SUBMITTER: Biler ED 

PROVIDER: S-EPMC5954398 | biostudies-literature | 2018 Mar-Apr

REPOSITORIES: biostudies-literature