Global Gene Expression Response in Mouse Models of DNA Repair Deficiency after Gamma Irradiation.

ABSTRACT: In the event of an improvised nuclear device or "dirty bomb" in a highly populated area, potentially hundreds of thousands of people will require screening to ensure that exposed individuals receive appropriate treatment. For this reason, there is a need to develop tools for high-throughput radiation biodosimetry. Gene expression represents an emerging approach to biodosimetry and could potentially provide an estimate of both absorbed dose and individual radiation-induced injury. Since approximately 2-4% of humans are thought to be radiosensitive, and would suffer greater radiological injury at a given dose than members of the general population, it is of interest to explore the potential impact of such sensitivity on the biodosimetric gene expression signatures being developed. In this st

SUBMITTER: Rudqvist N 

PROVIDER: S-EPMC5954417 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature