Carnosic Acid, a Natural Diterpene, Attenuates Arsenic-Induced Hepatotoxicity via Reducing Oxidative Stress, MAPK Activation, and Apoptotic Cell Death Pathway.

ABSTRACT: The present studies have been executed to explore the protective mechanism of carnosic acid (CA) against NaAsO₂-induced hepatic injury. CA exhibited a concentration dependent (1-4 μM) increase in cell viability against NaAsO₂ (12 μM) in murine hepatocytes. NaAsO₂ treatment significantly enhanced the ROS-mediated oxidative stress in the hepatic cells both in in vitro and in vivo systems. Significant activation of MAPK, NF-κB, p53, and intrinsic and extrinsic apoptotic signaling was observed in NaAsO₂-exposed hepatic cells. CA could significantly counteract with redox stress and ROS-mediated signaling and thereby attenuated NaAsO₂-mediated hepatotoxicity. NaAsO₂ (10 mg/kg) treatment caused si

SUBMITTER: Das S 

PROVIDER: S-EPMC5954942 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature