Analysis of long non-coding RNA expression profiles following focal cerebral ischemia in mice.

ABSTRACT: Long noncoding RNAs (lncRNAs) have a variety of biological functions and play key roles in many diseases. However, the knowledge of lncRNA function during a stroke is limited. We analyzed the expression profiles of lncRNAs in the brain ischemic region of mice after a 45min middle cerebral artery occlusion (MCAO) with a 48h reperfusion. Gene ontology and pathway analysis were used to elucidate the potential functions of the differentially expressed mRNAs. A total of 255 lncRNAs (217 up-regulated and 38 down-regulated) and 894 mRNAs (870 up-regulated and 24 down-regulated) showed significantly altered expression in the ischemic brain compared to the sham controls (fold change ≫>2, P≪0.05). The gene ontology terms were mainly associated with neutrophil chemotaxis, positive regulation of infla

SUBMITTER: Liu C 

PROVIDER: S-EPMC5955004 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature