Comparative Histopathologic Lesions of the Male Reproductive Tract during Acute Infection of Zika Virus in AG129 and Ifnar^-/- Mice.

ABSTRACT: An understanding of the pathogenesis of infection with the Zika virus in the male reproductive tract is vital for the development of vaccines and antivirals that will limit or prevent sexual transmission. Two common immunocompromised mouse strains used in transmission studies-male with genes encoding interferon types I and II receptor gene knockout (IFNAR/IFNGR; AG129) and with interferon type 1 receptor knockout (Ifnar^-/-) were infected with a Puerto Rican Zika virus isolate (PRVABC59), and pathology was assessed 5 to 11 days after infection. Virus was detected by immunohistochemistry and quantitative RT-PCR in the testicle and epididymis of AG129 and Ifnar^-/- mice, and by immunohistochemistry in the prostate and seminal vesicle of infected AG129 mice. Severe disease

SUBMITTER: Clancy CS 

PROVIDER: S-EPMC5955007 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature