Breast cancer stem cell-like cells generated during TGFβ-induced EMT are radioresistant.

ABSTRACT: Failure of conventional antitumor therapy is commonly associated with cancer stem cells (CSCs), which are often defined as inherently resistant to radiation and chemotherapeutic agents. However, controversy about the mechanisms involved in the radiation response remains and the inherent intrinsic radioresistance of CSCs has also been questioned. These discrepancies observed in the literature are strongly associated with the cell models used. In order to clarify these contradictory observations, we studied the radiosensitivity of breast CSCs using purified CD24^-/low/CD44⁺ CSCs and their corresponding CD24⁺/CD44^low non-stem cells. These cells were generated after induction of the epithelial-mesenchymal transition (EMT) by transforming growth factor

SUBMITTER: Konge J 

PROVIDER: S-EPMC5955125 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature