High-throughput 3-dimensional culture of epithelial ovarian cancer cells as preclinical model of disease.

ABSTRACT:

Background

Recent reports have identified distinct genomic patterns in ovarian carcinoma, including proliferative and mesenchymal-like groups, with worse outcome. The exact mechanisms driving the onset and progression of these tumors are still poorly understood. Additionally, researchers are concerned about the correct subtype stratification of the available cell line models, and the exploration of alternatives to monolayer culture. Identification of biomarkers to stratify cell lines, characterization of important processes as epithelial-mesenchymal transition (EMT), and the use of three-dimensional (3D) cultures as alternative models could be useful for cell line classification.

Methods and results

In this work, we present a descriptive analysis of 16 commonly used ovarian

SUBMITTER: Heredia-Soto V 

PROVIDER: S-EPMC5955171 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature