Effects of cannabinoid receptor type 2 in respiratory syncytial virus infection in human subjects and mice.

ABSTRACT: An accumulating body of evidence suggests that the endocannabinoid system plays a significant role in pathophysiological processes and impacts disease severity. Here we investigate the possible role of a cannabinoid receptor type 2 (CB2) functional variant in determining disease severity and the potential pharmacological therapeutic effects of CB2 activation in viral respiratory infection. The common missense variant (CAA/CGG; Q63R) of the gene-encoding CB2 receptor (CNR2) was evaluated in 90 inpatient and 90 outpatient children with acute respiratory tract infection (ARTI). The frequency distribution of respiratory syncytial virus (RSV)-the main cause of severe cases of bronchiolitis and pneumonia in children-was studied in all collected samples. The mechanism through which CB2 affects cl

SUBMITTER: Tahamtan A 

PROVIDER: S-EPMC5955186 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature