Modulatory upregulation of an insulin peptide gene by different pathogens in C. elegans.

ABSTRACT: When an animal is infected, its innate immune response needs to be tightly regulated across tissues and coordinated with other aspects of organismal physiology. Previous studies with Caenorhabditis elegans have demonstrated that insulin-like peptide genes are differentially expressed in response to different pathogens. They represent prime candidates for conveying signals between tissues upon infection. Here, we focused on one such gene, ins-11 and its potential role in mediating cross-tissue regulation of innate immune genes. While diverse bacterial intestinal infections can trigger the up-regulation of ins-11 in the intestine, we show that epidermal infection with the fungus Drechmeria coniospora triggers an upregulation of ins-11 in the epidermis. Using the Shigella virulence factor Ops

SUBMITTER: Lee SH 

PROVIDER: S-EPMC5955453 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature