Evaluating Vaccination Strategies for Zika Virus in the Americas.

ABSTRACT:

Background

Mosquito-borne and sexually transmitted Zika virus has become widespread across Central and South America and the Caribbean. Many Zika vaccine candidates are under active development.

Objective

To quantify the effect of Zika vaccine prioritization of females aged 9 to 49 years, followed by males aged 9 to 49 years, on incidence of prenatal Zika infections.

Design

A compartmental model of Zika transmission between mosquitoes and humans was developed and calibrated to empirical estimates of country-specific mosquito density. Mosquitoes were stratified into susceptible, exposed, and infected groups; humans were stratified into susceptible, exposed, infected, recovered, and vaccinated groups. Age-specific fertility rates, Zika sexual transmission, and country-s

SUBMITTER: Durham DP 

PROVIDER: S-EPMC5955609 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature