Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis.

ABSTRACT:

Background

Calcific atherosclerosis is a major challenge to intraluminal drug delivery in peripheral artery disease (PAD).

Objectives

We evaluated the effects of orbital atherectomy on intraluminal paclitaxel delivery to human peripheral arteries with substantial calcified plaque.

Methods

Diagnostic angiography and 3-D rotational imaging of five fresh human lower limbs revealed calcification in all main arteries. The proximal or distal segment of each artery was treated using an orbital atherectomy system (OAS) under simulated blood flow and fluoroscopy. Explanted arterial segments underwent either histomorphometric assessment of effect or tracking of ¹⁴C-labeled or fluorescent-labeled paclitaxel. Radiolabeled drug quantified bulk delivery and fluorescent l

SUBMITTER: Tzafriri AR 

PROVIDER: S-EPMC5955709 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature