Severity of gastric mucosal atrophy affects the healing speed of post-endoscopic submucosal dissection ulcers.

ABSTRACT: AIM:To investigate factors associated with the healing of endoscopic submucosal dissection (ESD)-induced ulcers. METHODS:We enrolled 132 patients with gastric tumors scheduled for ESD. Following ESD, patients were treated with daily lansoprazole 30 mg or vonoprazan 20 mg. Ulcer size was endoscopically measured on the day after ESD and at 4 and 8 wk. The gastric mucosa was endoscopically graded according to the Kyoto gastritis scoring system. We assessed the number of patients with and without a 90% reduction in ulcer area at 4 wk post-ESD and scar formation at 8 wk, and looked for risk factors for slower healing. RESULTS:The mean size of gastric tumors and post-ESD ulcers was 17.4 ± 12.1 mm and 32.9 ± 13.0 mm. The mean reduction rates in ulcer area were 90.4% ± 0.8% at 4 wk and 99.8% ± 0.1

SUBMITTER: Otsuka T 

PROVIDER: S-EPMC5955726 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature