Forms and functions of store-operated calcium entry mediators, STIM and Orai.

ABSTRACT: Calcium signals arise by multiple mechanisms, including mechanisms of release of intracellular stored Ca²⁺, and the influx of Ca²⁺ through channels in the plasma membrane. One mechanism that links these two sources of Ca²⁺ is store-operated Ca²⁺ entry, the most commonly encountered version of which involves the extensively studied calcium-release-activated Ca²⁺ (CRAC) channel. The minimal and essential molecular components of the CRAC channel are the STIM proteins that function as Ca²⁺ sensors in the endoplasmic reticulum, and the Orai proteins that comprise the pore forming subunits of the CRAC channel. CRAC channels are known to play significant roles in a wide variety of physiological functions. This review discusses the

SUBMITTER: Putney JW 

PROVIDER: S-EPMC5955777 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature