Replication in Imaging Genetics: The Case of Threat-Related Amygdala Reactivity.

ABSTRACT:

Background

Low replication rates are a concern in most, if not all, scientific disciplines. In psychiatric genetics specifically, targeting intermediate brain phenotypes, which are more closely associated with putative genetic effects, was touted as a strategy leading to increased power and replicability. In the current study, we attempted to replicate previously published associations between single nucleotide polymorphisms and threat-related amygdala reactivity, which represents a robust brain phenotype not only implicated in the pathophysiology of multiple disorders, but also used as a biomarker of future risk.

Methods

We conducted a literature search for published associations between single nucleotide polymorphisms and threat-related amygdala reactivity and found 37 uni

SUBMITTER: Avinun R 

PROVIDER: S-EPMC5955809 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature