Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.

ABSTRACT: Impaired capacity to increase heart rate (HR) during exercise (ΔHR^ex), and a reduced rate of recovery post-exercise (ΔHR^rec) are associated with higher cardiovascular mortality rates. Currently, the genetic basis of both phenotypes remains to be elucidated. We conduct genome-wide association studies (GWASs) for ΔHR^ex and ΔHR^rec in ~40,000 individuals, followed by replication in ~27,000 independent samples, all from UK Biobank. Six and seven single-nucleotide polymorphisms for ΔHR^ex and ΔHR^rec, respectively, formally replicate. In a full data set GWAS, eight further loci for ΔHR^ex and nine for ΔHR^rec are genome-wide significant (P ≤ 5 × 10^-8). In total, 30 loci are discovered, 8 being common a

SUBMITTER: Ramirez J 

PROVIDER: S-EPMC5955978 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature