Association of Whole Blood Tacrolimus Concentrations with Kidney Injury in Heart Transplantation Patients.

ABSTRACT:

Background and objectives

Acute kidney injury (AKI) is frequently observed after heart transplantation and is associated with morbidity and mortality. However, many confounding factors also contribute to the development of AKI in heart transplants. We hypothesized that supratherapeutic whole-blood tacrolimus trough concentrations are associated with AKI.

Methods

In a retrospective observational cohort from April 2005 to December 2012, all adult heart transplantation patients were included. AKI was assessed in the first 2 weeks after transplantation as classified by the Kidney Disease Improving Global Outcomes Network (KDIGO). Whole-blood tacrolimus trough concentrations were determined from day 1 to day 14 and at 1, 3, 6 and 12 months post-transplantation. The therapeutic ra

SUBMITTER: Sikma MA 

PROVIDER: S-EPMC5956048 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature