Macrophages and Dendritic Cells Are the Predominant Cells Infected in Measles in Humans.

ABSTRACT: Characterization of human measles cases is essential in order to better assess the data generated in model systems of morbillivirus infection. To this end, we collected formalin-fixed tissue samples from 23 natural measles cases from different areas in the world and different phases of disease ranging from prodromal and acute measles to a persistent infection in an immunocompromised subject. We show that the vast majority of measles virus (MV)-infected cells in epithelia were intraepithelial immune cells that were, in most cases, positive for the CD11c myeloid cell marker. Small numbers of measles virus-infected cytokeratin-positive epithelial cells were also detected in bronchial and appendix epithelia. Dissolution and disruption of uninfected and MV-infected alveolar and bronchial epithe

SUBMITTER: Allen IV 

PROVIDER: S-EPMC5956143 | biostudies-literature | 2018 May-Jun

REPOSITORIES: biostudies-literature