TosR-Mediated Regulation of Adhesins and Biofilm Formation in Uropathogenic Escherichia coli.

ABSTRACT: Uropathogenic Escherichia coli strains utilize a variety of adherence factors that assist in colonization of the host urinary tract. TosA (type one secretion A) is a nonfimbrial adhesin that is predominately expressed during murine urinary tract infection (UTI), binds to kidney epithelial cells, and promotes survival during invasive infections. The tosRCBDAEF operon encodes the secretory machinery necessary for TosA localization to the E. coli cell surface, as well as the transcriptional regulator TosR. TosR binds upstream of the tos operon and in a concentration-dependent manner either induces or represses tosA expression. TosR is a member of the PapB family of fimbrial regulators that can participate in cross talk between fim

SUBMITTER: Luterbach CL 

PROVIDER: S-EPMC5956150 | biostudies-literature | 2018 May-Jun

REPOSITORIES: biostudies-literature