Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms.

ABSTRACT: Obesity and diabetes are major challenges to global health, and there is an urgent need for interventions that promote weight loss. Dietary restriction of methionine promotes leanness and improves metabolic health in mice and humans. However, poor long-term adherence to this diet limits its translational potential. In this study, we develop a short-term methionine deprivation (MD) regimen that preferentially reduces fat mass, restoring normal body weight and glycemic control to diet-induced obese mice of both sexes. The benefits of MD do not accrue from calorie restriction, but instead result from increased energy expenditure. MD promotes increased energy expenditure in a sex-specific manner, inducing the fibroblast growth factor (Fgf)-21-uncoupling protein (Ucp)-1 axis only in males. Meth

SUBMITTER: Yu D 

PROVIDER: S-EPMC5956241 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature