Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer's Disease.

ABSTRACT: Network hyperexcitability is a feature of Alzheimer' disease (AD) as well as numerous transgenic mouse models of AD. While hyperexcitability in AD patients and AD animal models share certain features, the mechanistic overlap remains to be established. We aimed to identify features of network hyperexcitability in AD models that can be related to epileptiform activity signatures in AD patients. We studied network hyperexcitability in mice expressing amyloid precursor protein (APP) with mutations that cause familial AD, and compared a transgenic model that overexpresses human APP (hAPP) (J20), to a knock-in model expressing APP at physiological levels (APP^NL/F). We recorded continuous long-term electrocorticogram (ECoG) activity from mice, and studied modulation by circadian cycle,

SUBMITTER: Brown R 

PROVIDER: S-EPMC5956746 | biostudies-literature | 2018 Mar-Apr

REPOSITORIES: biostudies-literature