Serum magnesium levels and risk of coronary artery disease: Mendelian randomisation study.

ABSTRACT:

Background

Observational studies have shown that serum magnesium levels are inversely associated with risk of cardiovascular disease, but whether this association is causal is unknown. We conducted a Mendelian randomisation study to investigate whether serum magnesium levels may be causally associated with coronary artery disease (CAD).

Methods

This Mendelian randomisation analysis is based on summary-level data from the CARDIoGRAMplusC4D consortium's 1000 Genomes-based genome-wide association meta-analysis of 48 studies with a total of 60,801 CAD cases and 123,504 non-cases. Six single-nucleotide polymorphisms associated with serum magnesium levels at genome-wide significance were used as instrumental variables.

Results

A genetic predisposition to higher serum magnes

SUBMITTER: Larsson SC 

PROVIDER: S-EPMC5956816 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature