Dysregulated invertebrate tropomyosin-dectin-1 interaction confers susceptibility to allergic diseases.

ABSTRACT: The key factors underlying the development of allergic diseases-the propensity for a minority of individuals to develop dysfunctional responses to harmless environmental molecules-remain undefined. We report a pathway of immune counter-regulation that suppresses the development of aeroallergy and shrimp-induced anaphylaxis. In mice, signaling through epithelially expressed dectin-1 suppresses the development of type 2 immune responses through inhibition of interleukin-33 (IL-33) secretion and the subsequent recruitment of IL-13-producing innate lymphoid cells. Although this homeostatic pathway is functional in respiratory epithelial cells from healthy humans, it is dramatically impaired in epithelial cells from asthmatic and chronic rhinosinusitis patients, resulting in elevated IL-33 prod

SUBMITTER: Gour N 

PROVIDER: S-EPMC5956913 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature