Cross-sectional and longitudinal atrophy is preferentially associated with tau rather than amyloid β positron emission tomography pathology.

ABSTRACT:

Introduction

Structural magnetic resonance imaging is a marker of gray matter health and decline that is sensitive to impaired cognition and Alzheimer's disease pathology. Prior work has shown that both amyloid β (Aβ) and tau biomarkers are related to cortical thinning, but it is unclear what unique influences they have on the brain.

Methods

Aβ pathology was measured with [¹⁸F] AV-45 (florbetapir) positron emission tomography (PET) and tau was assessed with [¹⁸F] AV-1451 (flortaucipir) PET in a population of 178 older adults, of which 123 had longitudinal magnetic resonance imaging assessments (average of 5.7 years) that preceded the PET acquisitions.

Results

In cross-sectional analyses, greater tau PET pathology was associated with thinner corti

SUBMITTER: Gordon BA 

PROVIDER: S-EPMC5956934 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature