Memory concerns in the early Alzheimer's disease prodrome: Regional association with tau deposition.

ABSTRACT:

Introduction

Relationship between self- and informant memory concerns and tau aggregation was assessed in adults at risk for Alzheimer's disease (AD).

Methods

Regional mean standardized uptake value ratios were extracted from [¹⁸F]flortaucipir positron emission tomography (PET) scans of 82 at-risk adults in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Associations between self- and informant ECog memory scores and tau aggregation were analyzed on both regional and voxelwise bases. Analyses were completed both on the whole sample and restricted to amyloid-positive individuals only.

Results

Memory concerns were associated with tau aggregation. Self-perception was more associated with frontal tau. In contrast, informant scores were more assoc

SUBMITTER: Swinford CG 

PROVIDER: S-EPMC5956937 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature